Hydrophobia or rabies caused by rabies virus into the family Rhabdoviridae and genus Lysavirus. The main characteristic of the virus family Rhabdoviridae is only one negative strand RNA that is not bersegmen. The virus lives in several animal species that acts as an intermediary for the transmission. Intermediary animal species vary in different geographical location. The animals are known to be a mediator of rabies include raccoons (Procyon lotor) and skunks (Memphitis memphitis) in North America, red foxes (Vulpes vulpes) in Europe, and dogs in Africa, Asia, and Latin America. Africa, Asia, and Latin America have a still higher level of rabies infected animals intermediary host may be other animals or humans through bites. Infection can also occur through animal licking an intermediary in the injured skin. After infection, the virus will enter through the nerves to the spinal cord and brain and replicate there. Furthermore, the virus will move back through the nerves to the non-neural tissues, such as salivary glands and into the saliva. Infected animals can experience a wild rabies / rabies malignant or benign / quiet. In the wild rabies / malignant, infected animals appear ferocious, aggressive, bite and swallow all kinds of goods, saliva kept dripping, nervous howling and then become paralyzed and die. In rabies benign / quiet, infected animals experienced local paralysis or total paralysis, like hiding in dark places, having seizures and difficulty breathing, and showed audacity.